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Rev. cuba. invest. bioméd ; 32(2): 139-146, abr.-jun. 2013.
Article in Spanish | LILACS | ID: lil-685975

ABSTRACT

Introducción: La infección por el virus de inmunodeficiencia humana (VIH) constituye un importante problema de salud. La capacidad funcional del sistema inmune declina gradualmente con el envejecimiento. Objetivo: Demostrar que los pacientes VIH/sida de la tercera edad, tratados con antirretrovirales, presentan disminución de la carga viral y aumento de los linfocitos T CD4+ con el uso del tratamiento. Métodos: Se realizó un estudio observacional prospectivo de corte transversal en 44 pacientes VIH/SIDA pertenecientes al servicio de Medicina del IPK que recibieron tratamiento con diferentes esquemas de antirretrovirales. Resultados: Se observó un incremento medio de linfocitos T CD4+ de 97 cel/µL así como una disminución media de carga viral de 3 583 cp/µL después del tratamiento antirretroviral. Conclusiones: Con este estudio podemos concluir que con el uso de la terapia antirretroviral en los pacientes VIH/sida de la tercera edad aumentaron los linfocitos T CD4+ y disminuyó la carga viral, lo que evidencia la reconstitución inmunológica y el control virológico de estos pacientes


Background: Infection with the Human Immunodeficiency Virus (HIV) is a major health problem. The functional capacity of the immune system gradually declines with aging. Objective: To demonstrate that the elderly patients with HIV/AIDS who follow treatment with antiretroviral drugs present a fall in viral load and a rise in the CD4+ T-lymphocytes with this treatment. Methods: A cross-sectional prospective observational study was conducted in 44 HIV/AIDS patients attended in the Medical Services offered by IPK who received treatment with different antiretroviral schemes. Results: It was observed that there was an average rise of 97 cel/µL in the CD4+ T-lymphocytes, as well as an average fall of 3 583 cp/µL in viral load after the antiretroviral treatment. Conclusions: With this study, we can conclude that there was a rise in CD4+ T-lymphocytes and a fall in the viral load in the elderly patients with HIV/AIDS who followed treatment with antiretroviral drugs, what evidences the immunological reconstitution and virologic control of these patients with the use of antiretroviral therapy


Subject(s)
Aged , Anti-Retroviral Agents , Anti-Retroviral Agents/therapeutic use , Viral Load , Health of the Elderly , HIV , Cross-Sectional Studies , Observational Studies as Topic , Prospective Studies
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